|NCCR Chemical Biology|
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The National Centre of Competence in Research (NCCR) «Chemical Biology – Visualisation and Control of Biological Processes Using Chemistry» uses chemistry tools to obtain a better understanding of life at the molecular level. Until now, a few technologies could characterise in detail the countless biochemical activities that constitute a living cell. In the NCCR Chemical Biology, chemists, biochemists, physicists and cell biologists develop innovative techniques based on small molecules and proteins to obtain new information about cellular processes and control them in situ. The new tools will be applicable to various biological phenomena like visualising the activity of selected proteins during cell division and investigating how membranes control the activity of proteins in them. The NCCR is also engaged in establishing a platform for chemical screening aimed at developing a new generation of molecules with biological effects. http://www.nccr-chembio.ch
Chemical Interference of Biological Systems with Natural Products
Non-essential Metals in Chemical Biology
Screening of Large Molecule Diversities by Phage Display
A Novel Strategy to Identify Drugs that Interfere with Endosomal Lipids
Chemical Biology Approaches to Membrane Homeostasis and Function
Conceptually New Entries into Cells
Putting the ‘P’ into Phospholipids
Exploring the Chemical Space of Known and Unknown Organic Small Molecules at www.gdb.unibe.ch
J.-L. Reymond*, L. C. Blum, R. van Deursen
Visualizing Biochemical Activities in Living Cells through Chemistry
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