Vol. 62 No. 5 (2008): NRP50: Endocrine Disruptors

Editorial

Endocrine Disruptors: Relevance to Humans, Animals and Ecosystems: Research Highlights from the National Research Programme NRP50 Editorial

Felix R. Althaus, Konrad Hungerbühler, Susan Jobling, Urs Ruegg, Ana Soto, Christoph Studer

316
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Scientific Articles

Introduction

Felix R. Althaus

318
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VirtualToxLab – in silico Prediction of the Endocrine-Disrupting Potential of Drugs and Chemicals

Angelo Vedani, Morena Spreafico, Ourania Peristera, Max Dobler, Martin Smiesko

322
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Identification of Endocrine-Disrupting Compounds Using Nanoelectrospray Ionization Mass Spectrometry

Cédric Bovet, Marc Ruff, Arno Wortmann, Sylvia Eiler, Florence Granger, Bertran Gerrits, Dino Moras, Renato Zenobi

329
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Disruption of Glucocorticoid and Mineralocorticoid Receptor-Mediated Responses by Environmental Chemicals

Alex Odermatt, Christel Gumy

335
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PPAR Disruption: Cellular Mechanisms and Physiological Consequences

Nicolas Rotman, Zofia Haftek-Terreau, Sandra Lücke, Jérôme Feige, Laurent Gelman, Béatrice Desvergne, Walter Wahli

340
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Endocrine Active UV Filters: Developmental Toxicity and Exposure Through Breast Milk

Margret Schlumpf, Jesus A. F. Tresguerres, Barry Timms, Armin Zenker, Sasha Reolon, Kirsten Maerkel, Luke Hofkamp, Manuel Henseler, Catherine Gaille, Michaela Fuetsch, Colin Ehnes, Oliver Faass, Stefan Durrer, Monika Birchler, Claudia C. Vökt, Karin Kypke, Walter Lichtensteigera

345
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Brominated Flame Retardants – Endocrine-Disrupting Chemicals in the Swiss Environment

Andreas C. Gereckea, Peter Schmid, Christian Bogdal, Martin Kohler, Markus Zennegg, Norbert V. Heeb

352
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ipso-Substitution – A Novel Pathway for Microbial Metabolism of Endocrine-Disrupting 4-Nonylphenols, 4-Alkoxyphenols, and Bisphenol A

Hans-Peter E. Kohler, Frédéric L. P. Gabriel, Walter Giger

358
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Environmental Exposure to Estrogenic and other Myco- and Phytotoxins

Niccolo Hartmann, Marianne Erbs, Felix E. Wettstein, Corinne C. Hörger, Susanne Vogelgsang, Hans-Rudolf Forrer, René P. Schwarzenbach, Thomas D. Bucheli

364
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UV Filters in the Aquatic Environment Induce Hormonal Effects and Affect Fertility and Reproduction in Fish

Karl Fent, Petra Y. Kunz, Elena Gomez

368
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Estrogenic Endocrine Disruption in Switzerland: Assessment of Fish Exposure and Effects

Patricia Burkhardt-Holm, Helmut Segner, Richard Burki, Armin Peter, Sara Schubert, Marc J.-F. Suter, Mark E. Borsuk

376
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Gonadal Malformations in Whitefish from Lake Thun: Defining the Case and Evaluating the Role of EDCs

Daniel Bernet, Thomas Wahli, Marc J.-F. Suter, Carlo R. Largiader, Christoph Küng, Sibylle Kipfer, Rik I. L. Eggen, David Bittner, Anja Liedtke, Helmut Segner

383
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Estrogens in Swiss Rivers and Effluents – Sampling Matters

Etiënne L. M. Vermeirssen, Rik I. L. Eggen, Beate I. Escher, Marc J.-F. Suter

389
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First Evaluation of Human Sperm Quality in Various Geographic Regions of Switzerland

Michel Crausaz, Josefina Vargas, Roumen Parapanov, Yves Chollet, Marc Wisard, Eric Stettler, Alfred Senn, Marc Germonda

395
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Diethylstilbestrol Action on Leydig Cell Function and Testicular Descent

Christopher R. Cederroth, Serge Nef

401
- PDF
Endocrine Disruptors and Breast Cancer

Cathrin Brisken

406
- PDF
Genetic Reprogramming of Human Mammary Cells by Environmental Carcinogens Released into Breast Milk

Ramiro Dip, Tonko Buterin, Daniela Wenger, Peter Schmid, Hanspeter Naegeli

410
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Integrative Risk Assessment of Endocrine Disruptors in Switzerland

René Gälli, Christian Braun

417
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Dynamic Substance Flow Analysis as a Valuable Risk Evaluation Tool – A Case Study for Brominated Flame Retardants as an Example of Potential Endocrine Disrupters

Leo S. Morf, Andreas M. Buser, Ruedi Taverna, Hans-Peter Bader, Ruth Scheidegger

424
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Results of the Consensus Platforms: Positions and Recommendations Derived from Scientific Findings in a Joint Effort of Academics, Industry, and Authorities

Marcel Trachsel

432
- PDF

Columns, Conference Reports

SWISS Science Concentrates SWISS Science Concentrates

Martina Austeri, Renaud Bach, Nathalie Mehanna, Roman Novikov, Ankit Sharma, Franck Torricelli, Jérôme Lacour

439
- PDF
The Mechanism of Chlorophyll Degradation in Plants Highlights of Analytical Chemistry in Switzerland

Stefan Hörtensteiner, Thomas Müller, Bernhard Kräutler

440
- PDF
Nanoparticulate Systems: A New Competence Platform at the University of Applied Sciences Northwestern Switzerland (FHNW) FH – HES

Patrick Shahgaldian, Amina Wirth, Uwe Pieles

441
- PDF
In Memoriam: Albert Hofmann (1906–2008)

Nathaniel S. Finney, Jay S. Siegel

444
- PDF

Community News

Generalversammlung der SCG

449
- PDF

CHIMIA Report/Company News

CHIMIA-Report Companies present themselves and their products

A453
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Vol. 62 No. 5 (2008): NRP50: Endocrine Disruptors

Editorial

Endocrine Disruptors: Relevance to Humans, Animals and Ecosystems: Research Highlights from the National Research Programme NRP50 Editorial

Scientific Articles

Introduction

VirtualToxLab – in silico Prediction of the Endocrine-Disrupting Potential of Drugs and Chemicals

Identification of Endocrine-Disrupting Compounds Using Nanoelectrospray Ionization Mass Spectrometry

Disruption of Glucocorticoid and Mineralocorticoid Receptor-Mediated Responses by Environmental Chemicals

PPAR Disruption: Cellular Mechanisms and Physiological Consequences

Endocrine Active UV Filters: Developmental Toxicity and Exposure Through Breast Milk

Brominated Flame Retardants – Endocrine-Disrupting Chemicals in the Swiss Environment

ipso-Substitution – A Novel Pathway for Microbial Metabolism of Endocrine-Disrupting 4-Nonylphenols, 4-Alkoxyphenols, and Bisphenol A

Environmental Exposure to Estrogenic and other Myco- and Phytotoxins

UV Filters in the Aquatic Environment Induce Hormonal Effects and Affect Fertility and Reproduction in Fish

Estrogenic Endocrine Disruption in Switzerland: Assessment of Fish Exposure and Effects

Gonadal Malformations in Whitefish from Lake Thun: Defining the Case and Evaluating the Role of EDCs

Estrogens in Swiss Rivers and Effluents – Sampling Matters

First Evaluation of Human Sperm Quality in Various Geographic Regions of Switzerland

Diethylstilbestrol Action on Leydig Cell Function and Testicular Descent

Endocrine Disruptors and Breast Cancer

Genetic Reprogramming of Human Mammary Cells by Environmental Carcinogens Released into Breast Milk

Integrative Risk Assessment of Endocrine Disruptors in Switzerland

Dynamic Substance Flow Analysis as a Valuable Risk Evaluation Tool – A Case Study for Brominated Flame Retardants as an Example of Potential Endocrine Disrupters

Results of the Consensus Platforms: Positions and Recommendations Derived from Scientific Findings in a Joint Effort of Academics, Industry, and Authorities

Columns, Conference Reports

SWISS Science Concentrates SWISS Science Concentrates

The Mechanism of Chlorophyll Degradation in Plants Highlights of Analytical Chemistry in Switzerland

Nanoparticulate Systems: A New Competence Platform at the University of Applied Sciences Northwestern Switzerland (FHNW) FH – HES

In Memoriam: Albert Hofmann (1906–2008)

Community News

Generalversammlung der SCG

CHIMIA Report/Company News

CHIMIA-Report Companies present themselves and their products

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