Vol. 60 No. 9 (2006): Process Chemistry

Editorial

Process Chemistry in API Development Editorial

Hans-Ruedi Marti, Jay S. Siegel

516
- PDF

Scientific Articles

Early Process Development: The Wyeth Approach

Michael K. O'Brien, Michael Kolb, Karen Sutherland, Kevin McCoy, Anthony Pilcher

518
- PDF
Process Development for Active Pharmaceutical Ingredients Following a Developmental Cascade

Carmen Adler, Jürg Brunner, Claudia Fichtner, Peter Küng, Michael K. Levis, Hans-Rudolf Ruchti, Anders Sjöberg, Beat Weber

523
- PDF
Process Development and Production Concepts for the Manufacturing of Organic Fine Chemicals at LONZA

Golo Heckmann, Felix Previdoli, Thomas Riedel, David Ruppen, Dario Veghini, Uwe Zacher

530
- PDF
Laboratory for Process Research – Ten Years of Successful Partnership between University of Zurich and the Pharmaceutical Industry

Thomas Bader

534
- PDF
A General Approach to Indoles: Practical Applications for the Synthesis of Highly Functionalized Pharmacophores

Jeffrey T. Kuethe

543
- PDF
Process Research and Scale-up of the κ-Opioid Receptor Agonist CJ-15,161 Drug Candidate

Brian M. Andresen, Brian C. Vanderplas, John L. Tucker, Janice E. Sieser, Maxime Riou, Teresa M. Makowski, Joel M. Hawkins, Melina Girardin, Arun Ghosh, Kristina Dupont-Gaudet, Nga M. Do, Keith M. DeVries, Michel Couturier, Stéphane Caron, Timothy J.N. Watson

554
- PDF
With Asymmetric Hydrogenation Towards a New, Enantioselective Synthesis of Orlistat

Rolf Birk, Martin Karpf, Kurt Püntener, Michelangelo Scalone, Mark Schwindt, Ulrich Zutter

561
- PDF
The Formation of a Crystalline Oxazolidin-5-one from (L)-Alanine and its Use as a Chiral Template in the Practical Synthesis of α-Substituted Alanine Esters

Magnus Eriksson, Elio Napolitano, Jinghua Xu, Suresh Kapadia, Denis Byrne, Laurence Nummy, Nelu Grinberg, Sherri Shen, Heewon Lee, Vittorio Farina

566
- PDF
Recent Optimization Highlights of the Georgywood Process

Jean-Pierre Barras, Bernadette Bourdin, Fridtjof Schröder

574
- PDF
An Asymmetric Synthesis of PPAR-? Agonist Navaglitazar from (+)-Methyl (2S,3R)-3-(4-methoxyphenyl)glycidate

John R. Rizzo, Tony Y. Zhang

580
- PDF
The Chemical Development of CHIR-258

Shuguang Zhu, Minna Zheng, Brian Diaz, Arthur Yeung, Li Jin, Gabriel Galvin, Xiao Shang, Shaopei Cai, Eric Harwood, David Ryckman

584
- PDF
An Improved Process for Repaglinide via an Efficient and One Pot Process of (1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine – A Useful Intermediate

Naveenkumar Kolla, Chandrashekar R. Elati, Pravinchandra J. Vankawala, Srinivas Gangula, Eswaraiah Sajja, Yerremilli Anjaneyulu, Apurba Bhattacharya, Venkataraman Sundaram, Vijayavitthal T. Mathad

593
- PDF
The Development of API Manufacturing Processes – Targets and Strategies

Dierk Wieckhusen

598
- PDF
Data-Oriented Process Development: Determination of Reaction Parameters by Small-Scale Calorimetry with in situ Spectroscopy

Graeme Puxty, Ulrich Fischer, Marc Jecklin, Konrad Hungerbühler

605
- PDF
Cost Analysis of a Commercial Manufacturing Process of a Fine Chemical Compound Using Micro Process Engineering

Ulrich Krtschil, Volker Hessel, Dana Kralisch, Günther Kreisel, Michael Küpper, Rainer Schenk

611
- PDF
Continuous Chemistry in Microreaction Systems for Practical Use

Gernot Müller, Theo Gaupp, Fabian Wahl, Gregor Wille

618
- PDF
Simulated Moving Bed Technology for the Industrial Small and Mid Scale Separation of Racemates

Patrick Kaiser

623
- PDF
Process Research in the Ivory Tower

Nathaniel S. Finney

628
- PDF

Columns, Conference Reports

Using Bacteria to Quantify Arsenic Contamination in Potable Water Highlights of Analytical Chemistry in Switzerland

Jan Roelof Van Der Meer, Michael Berg, Pham Thi Kim Trang

631
- PDF

Community News

Ausserordentliche Generalversamlung der SCG

633
- PDF

Events

News - Lectures - Conferences

634
- PDF

CHIMIA Report/Company News

Chimia-Report Companies present themselves and their products

636
- PDF

Vol. 60 No. 9 (2006): Process Chemistry

Editorial

Process Chemistry in API Development Editorial

Scientific Articles

Early Process Development: The Wyeth Approach

Process Development for Active Pharmaceutical Ingredients Following a Developmental Cascade

Process Development and Production Concepts for the Manufacturing of Organic Fine Chemicals at LONZA

Laboratory for Process Research – Ten Years of Successful Partnership between University of Zurich and the Pharmaceutical Industry

A General Approach to Indoles: Practical Applications for the Synthesis of Highly Functionalized Pharmacophores

Process Research and Scale-up of the κ-Opioid Receptor Agonist CJ-15,161 Drug Candidate

With Asymmetric Hydrogenation Towards a New, Enantioselective Synthesis of Orlistat

The Formation of a Crystalline Oxazolidin-5-one from (L)-Alanine and its Use as a Chiral Template in the Practical Synthesis of α-Substituted Alanine Esters

Recent Optimization Highlights of the Georgywood Process

An Asymmetric Synthesis of PPAR-? Agonist Navaglitazar from (+)-Methyl (2S,3R)-3-(4-methoxyphenyl)glycidate

The Chemical Development of CHIR-258

An Improved Process for Repaglinide via an Efficient and One Pot Process of (1S)-3-methyl-1-(2-piperidin-1-ylphenyl)butan-1-amine – A Useful Intermediate

The Development of API Manufacturing Processes – Targets and Strategies

Data-Oriented Process Development: Determination of Reaction Parameters by Small-Scale Calorimetry with in situ Spectroscopy

Cost Analysis of a Commercial Manufacturing Process of a Fine Chemical Compound Using Micro Process Engineering

Continuous Chemistry in Microreaction Systems for Practical Use

Simulated Moving Bed Technology for the Industrial Small and Mid Scale Separation of Racemates

Process Research in the Ivory Tower

Columns, Conference Reports

Using Bacteria to Quantify Arsenic Contamination in Potable Water Highlights of Analytical Chemistry in Switzerland

Community News

Ausserordentliche Generalversamlung der SCG

Events

News - Lectures - Conferences

CHIMIA Report/Company News

Chimia-Report Companies present themselves and their products

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