Vol. 46 No. 7-8 (1992): XIIth International Symposium on Medicinal Chemistry

Published: 1992-08-19

Editorial

Welcome to the XIIth International Symposium on Medicinal Chemistry Editorial

Emilio Kyburz, Bernard Testa

295
- PDF

Forschung

Medicinal Chemistry: A Teacher's and Worker's Perspective

Bernard Testa

297
- PDF
Hydrogen-Bonding Capacity and Brain Penetration

Han van de Waterbeemd, Manfred Kansy

299
- PDF
Peptidoleukotriene Antagonists State of the Art

Andreas von Sprecher, Andreas Beck, Marc Gerspacher, Michael A. Bray

304
- PDF
(Trimethylsilyl)alanine: a Metabolically Stable 'Bio-Isostere' for Phenylalanine

Beat Weidmann

312
- PDF
Structure of Cyclosporine and Its Metabolites: Total Synthesis of Cyclosporine Metabolites Formed by Oxidation at Positions 4 and 9 of Cyclosporine. Preparation of Leucine-4-cyclosporine, (γ-Hydroxy)-N-methyl-leucine-9-cyclosporine and Leucine-4-(γ-hydroxy)-N-methyl-leucine-9-cyclosporine

Roland M. Wenger, Kurt Martin, Charles Timbers, Anne Tromelin

314
- PDF
Isosterism and Bioisosterism Case Studies with Muscarinic Agonists

Philipp Floersheim, Esteban Pombo-Villar, Gideon Shapiro

323
- PDF
The Fragmentation of 2,3-Dihydroisothiazol-3-one 1,1-Dioxide Derivatives: A Novel Cheletropic Process

Kaspar F. Burri

335
- PDF
Concept and Development of a Potent Topical Corticosteroid

Jaroslav Kalvoda, Jürgen Grob, Klaus Jäkel, Peter Moser, Hermann Fuhrer, Erich G. Weirich, Shantaram J. Yawalkar

338
- PDF

Community News

Alan Francis Thomas 1928–1992 Obituary

345
- PDF

CHIMIA Report/Company News

CHIMIA-Report Companies present themselves and their products

A356
- PDF