TY - JOUR AU - Baudoin, Olivier PY - 2021/11/11 Y2 - 2024/03/29 TI - A Personal Account on Industrial Collaborations in the Field of C–H Activation JF - CHIMIA JA - Chimia VL - 75 IS - 11 SE - Scientific Articles DO - 10.2533/chimia.2021.967 UR - https://www.chimia.ch/chimia/article/view/2021_967 SP - 967 AB - <div><span lang="EN-US">In recent years, transition-metal-catalyzed C–H functionalization has emerged as a potentially greener alternative to classic cross-couplings and as a powerful tool to access complex functional molecules with improved step-economy. This short account relates our experience of industrial collaborations in C(sp<sup>3</sup>)–H bond activation, which were key to the development of this topic in our group. The synthesis of the antianginal drug Ivabradine led us to develop a general approach to benzocyclobutenes, which were further employed in pericyclic reactions. A follow-up study led us to discover a new method to construct arylcyclopropanes via double C–H activation and the coupling of two alkyl groups. Finally, targeting the herbicide Indaziflam contributed to develop C(sp<sup>3</sup>)–H activation as a powerful tool to access a variety of relevant indane motifs. We hope that these successful stories will help to stimulate further fruitful Industry-Academia collaborations in the field of synthetic chemistry.</span></div> ER -