TY - JOUR AU - Hu, Xile PY - 2010/04/28 Y2 - 2024/03/29 TI - Cross Coupling of Non-Activated Alkyl Halides by a Nickel Pincer Complex JF - CHIMIA JA - Chimia VL - 64 IS - 4 SE - Scientific Articles DO - 10.2533/chimia.2010.231 UR - https://www.chimia.ch/chimia/article/view/2010_231 SP - 231 AB - Non-activated alkyl halides are challenging substrates for cross-coupling reactions because they are reluctant to undergo oxidative addition and because metal alkyl intermediates are prone to ?-H elimination. Despite recent progress, well-defined catalysts are rare. We recently prepared Ni complexes with a chelating pincer-type bis(amino)amide ligand. The chloride complex [(MeNN2)NiCl] is an active (pre)catalyst for the coupling of non-activated alkyl halides with alkyl, aryl, and heteroaryl Grignard reagents. The catalysis tolerates a wide range of functional groups such as keto, ester, amide, acetal, indole, furan, nitrile, etc. The Ni complex also catalyzes direct alkylation of alkynes and aromatic heterocycles. ER -