TY - JOUR AU - Langenegger, Simon M. AU - Bianké, Gapian AU - Tona, Rolf AU - Häner, Robert PY - 2005/11/01 Y2 - 2024/03/29 TI - DNA Mimics Containing Non-Nucleosidic Base Surrogates JF - CHIMIA JA - Chimia VL - 59 IS - 11 SE - Scientific Articles DO - 10.2533/000942905777675651 UR - https://www.chimia.ch/chimia/article/view/2005_794 SP - 794 AB - Chemically modified nucleic acids find widespread use as tools in research, as diagnostic reagents and as pharmaceutical compounds. While the major efforts in the past concentrated on the generation of sugar-based nucleotide analogues, the potential of non-nucleosidic and non-hydrogen bonding building blocks is largely untouched to date. Such derivatives may have an impact in the fields of materials and genetic research. In this paper, some recent findings of our work in this area are highlighted. ER -