TY - JOUR AU - van de Waterbeemd, Han AU - Kansy, Manfred PY - 1992/08/19 Y2 - 2024/03/29 TI - Hydrogen-Bonding Capacity and Brain Penetration JF - CHIMIA JA - Chimia VL - 46 IS - 7-8 SE - Forschung DO - 10.2533/chimia.1992.299 UR - https://www.chimia.ch/chimia/article/view/1992_299 SP - 299 AB - <p>Brain penetration has been reported to correlate with Δlog P, defined as log P (octan-1-ol/H<sub>2</sub>O) – log P (alkane/H<sub>2</sub>O). Another recent development, describing log P as the Sum of a cavity or volume contribution and H-bonding capability, the latter expressed by A<sub>solvent</sub> values, prompted us to reinvestigate the properties accounting for brain penetration. It was found that A<sub>alkane</sub> and the hydrophilic part of the <em>van der Waals</em> surface both correlate well with brain uptake. These findings offer new opportunities for the design of compounds which either should or should not be active at sites located in the brain.</p> ER -