TY - JOUR AU - Milosevic, Ana AU - Bourquin, Joël AU - Burnand, David AU - Lemal, Philipp AU - Crippa, Federica AU - Monnier, Christophe A. AU - Rodriguez-Lorenzo, Laura AU - Petri-Fink, Alke AU - Rothen-Rutishauser, Barbara PY - 2019/02/27 Y2 - 2024/03/29 TI - Artificial Lysosomal Platform to Study Nanoparticle Long-term Stability JF - CHIMIA JA - Chimia VL - 73 IS - 1-2 SE - Scientific Articles DO - 10.2533/chimia.2019.55 UR - https://www.chimia.ch/chimia/article/view/2019_055 SP - 55 AB - <p>Nanoparticles (NPs) possess unique properties useful for designing specific functionalities for biomedical applications. A prerequisite of a safe-by-design and effective use in any biomedical application is to study NP–cell interactions to gain a better understanding of cellular consequences upon exposure. Cellular uptake of NPs results mainly in the localization of NPs in the complex environment of lysosomes, a compartment which can be mimicked by artificial lysosomal fluid. In this work we showed the applicability of lysosomal fluid as a platform for a fast assessment of gold, iron oxide and silica NP stability over 24 h in a relevant biological fluid, by using multiple analytical methods.</p> ER -