@article{Gössi_Scherer_Schlotterbeck_2012, title={Thin-layer Chromatography–Nuclear Magnetic Resonance Spectroscopy – A Versatile Tool for Pharmaceutical and Natural Products Analysis: FH – HES Universities of Applied Sciences}, volume={66}, url={https://www.chimia.ch/chimia/article/view/2012_347}, DOI={10.2533/chimia.2012.347}, abstractNote={ Thin-layer chromatography (TLC) is a mature and very established technique, frequently used in many fields of applications ranging from natural product analysis to chemical or pharmaceutical applications. The introduction of a commercially available TLC–MS interface was a major step complementing the ease of use of TLC with structural elucidation power of mass spectrometry (MS). The TLC-MS interface simplifies the workflow dramatically to gain structural information directly from TLC separations. This article describes the potential of TLC-nuclear magnetic resonance spectroscopy (NMR) utilizing the TLC-MS interface to straightforwardly characterize zones of interest by NMR spectroscopy with a focus on quantification of active pharmaceutical ingredients (API) in formulations and identification of active principles in plant extracts. }, number={5}, journal={CHIMIA}, author={Gössi, Angelo and Scherer, Uta and Schlotterbeck, Götz}, year={2012}, month={May}, pages={347} }