Skeletal Editing of Heterocycles – A New Tool for Lead Exploration?

Medicinal Chemistry and Chemical Biology Highlights

Authors

  • Simon R. Williams Syngenta Crop Protection AG, Schaffhauserstrasse 101, CH-4332 Stein.
  • Julien C. Vantourout Syngenta Crop Protection AG, Schaffhauserstrasse 101, CH-4332 Stein.

DOI:

https://doi.org/10.2533/chimia.2024.446

Keywords:

Heterocyclic chemistry, Lead Exploration, Medicinal chemistry, Skeletal editing, Synthesis

Abstract

Many new methods for single atom skeletal editing of heterocycles have been developed in the past few years with obvious applications to discovery chemistry. In this perspective, we assess the recent advances in this field and the potential application to lead exploration campaigns.

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Published

2024-06-26

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