Flipper Probes for the Community

Authors

  • Lea Assies National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Organic Chemistry, University of Geneva
  • José García-Calvo National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Organic Chemistry, University of Geneva
  • Francesca Piazzolla National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Organic Chemistry, University of Geneva;
  • Samantha Sanchez National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Organic Chemistry, University of Geneva
  • Takehiro Kato National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Organic Chemistry, University of Geneva
  • Luc Reymond National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Spirochrome AG, Chalberwiesenstrasse 4, CH-8260 Stein am Rhein
  • Antoine Goujon National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Organic Chemistry, University of Geneva
  • Adai Colom National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Biochemistry, University of Geneva
  • Javier López-Andarias National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Organic Chemistry, University of Geneva
  • Karolína Straková National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Organic Chemistry, University of Geneva
  • Dora Mahecic National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; École Polytechnique Fédérale de Lausanne – EPFL, SB Cubotron 427, CH-1015 Lausanne
  • Vincent Mercier National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Biochemistry, University of Geneva
  • Margot Riggi National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Biochemistry, University of Geneva; Department of Molecular Biology, University of Geneva
  • Noemi Jiménez-Rojo National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Biochemistry, University of Geneva
  • Chloé Roffay National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Biochemistry, University of Geneva
  • Giuseppe Licari Department of Physical Chemistry, University of Geneva
  • Maria Tsemperouli National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva; Department of Chemistry, University of Fribourg, 9 Chemin du Musée, CH-1700 Fribourg
  • Frederik Neuhaus National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva; Department of Chemistry, University of Fribourg, 9 Chemin du Musée, CH-1700 Fribourg
  • Alexandre Fürstenberg Department of Physical Chemistry, University of Geneva; Department of Inorganic and Analytical Chemistry, University of Geneva
  • Eric Vauthey Department of Physical Chemistry, University of Geneva
  • Sascha Hoogendoorn National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Organic Chemistry, University of Geneva
  • Marcos Gonzalez-Gaitan National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Biochemistry, University of Geneva
  • Andreas Zumbuehl National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva; Department of Chemistry, University of Fribourg, 9 Chemin du Musée, CH-1700 Fribourg
  • Kaori Sugihara National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva; Department of Physical Chemistry, University of Geneva
  • Jean Gruenberg National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Biochemistry, University of Geneva
  • Howard Riezman National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Biochemistry, University of Geneva
  • Robbie Loewith National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva; Department of Molecular Biology, University of Geneva
  • Suliana Manley National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; École Polytechnique Fédérale de Lausanne – EPFL, SB Cubotron 427, CH-1015 Lausanne
  • Aurelien Roux National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Biochemistry, University of Geneva
  • Nicolas Winssinger National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Organic Chemistry, University of Geneva
  • Naomi Sakai National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Organic Chemistry, University of Geneva
  • Stefan Pitsch Spirochrome AG, Chalberwiesenstrasse 4, CH-8260 Stein am Rhein
  • Stefan Matile National Centre of Competence in Research (NCCR) Chemical Biology, 30 Quai Ernest-Ansermet, CH-1211 Geneva, Switzerland; Department of Organic Chemistry, University of Geneva

DOI:

https://doi.org/10.2533/chimia.2021.1004

Keywords:

Flipper probes, Fluorescence imaging, NCCR Chemical Biology

Abstract

This article describes four fluorescent membrane tension probes that have been designed, synthesized, evaluated, commercialized and applied to current biology challenges in the context of the NCCR Chemical Biology.  Their names are Flipper-TR©, ER Flipper-TR©, Lyso Flipper-TR© and Mito Flipper-TR©, they are available from Spirochrome.

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Published

2021-12-09

How to Cite

[1]
L. Assies, J. García-Calvo, F. Piazzolla, S. Sanchez, T. Kato, L. Reymond, A. Goujon, A. Colom, López-Andarias J., K. Straková, D. Mahecic, V. Mercier, M. Riggi, N. Jiménez-Rojo, C. Roffay, G. Licari, M. Tsemperouli, F. Neuhaus, A. Fürstenberg, E. Vauthey, S. Hoogendoorn, M. Gonzalez-Gaitan, A. Zumbuehl, K. Sugihara, J. Gruenberg, H. Riezman, R. Loewith, S. Manley, A. Roux, N. Winssinger, N. Sakai, S. Pitsch, S. Matile, Chimia 2021, 75, 1004, DOI: 10.2533/chimia.2021.1004.