Physiological and Molecular Function of the Sodium/Hydrogen Exchanger NHA2 (SLC9B2)

Authors

  • Tin Manh Ho Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern https://orcid.org/0000-0003-1608-2234
  • Stephan Berger Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Switzerland
  • Philipp Müller Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Switzerland
  • Céline Simonin Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Switzerland
  • Jean-Louis Reymond Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Switzerland https://orcid.org/0000-0003-2724-2942
  • Christoph von Ballmoos Department of Chemistry, Biochemistry and Pharmaceutical Sciences, University of Bern, Switzerland
  • Daniel G. Fuster Department of Nephrology and Hypertension, Inselspital, Bern University Hospital, University of Bern https://orcid.org/0000-0001-7220-1803

DOI:

https://doi.org/10.2533/chimia.2022.1019

PMID:

38069797

Keywords:

Blood pressure homeostasis, Bone, β-Cell, Insulin secretion, Kidney, Na⁺/H⁺ exchanger, NHA2, NHE, Osteoclast, SLC9B2

Abstract

NHA2, also known as SLC9B2, is an orphan intracellular Na+/H+ exchanger (NHE) that has been associated with arterial hypertension and diabetes mellitus in humans. The objective of this NCCR TransCure project was to define the physiological and molecular function of NHA2, to develop a high resolution kinetic transport assay for NHA2 and to identify specific and potent compounds targeting NHA2. In this review, we summarize the results of this highly interdisciplinary and interfaculty effort, led by the groups of Proffs. Jean-Louis Reymond, Christoph von Ballmoos and Daniel Fuster.

CHIMIA Vol. 76 No. 12 (2022): NCCR TransCure - Excellence in Membrane Transport Research 2010-2022

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Published

2022-12-21

Issue

Vol. 76 No. 12 (2022): NCCR TransCure - Excellence in Membrane Transport Research 2010-2022

Section

Scientific Articles

License

Copyright (c) 2022 Tin Manh Ho, Stephan Berger, Philipp Müller, Céline Simonin, Jean-Louis Reymond, Christoph von Ballmoos, Daniel G. Fuster

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
T. M. Ho, S. Berger, P. Müller, C. Simonin, J.-L. Reymond, C. von Ballmoos, D. G. Fuster, Chimia 2022, 76, 1019, DOI: 10.2533/chimia.2022.1019.