Preparation of Novel Enantiopure Ferrocenyl-Based Ligands for Asymmetric Catalysis

Abstract

Novel enantiopure ferrocene-based aminophosphine and diphosphine ligands for asymmetric catalysts have been developed. In all cases a highly flexible synthetic approach allowed access to ligands with different ferrocenyl backbones and with a variety of functional group patterns. Procedures for the synthesis of six families of ligands with either a homo- or heteroannularly bridged ferrocene, ferrocenylmethyl, biferrocene, biferroceno-azepine or ferrocenyl-aryl framework are described in detail.