Preparation of a Key Intermediate for the Angiotensin II Antagonist Losartan via Vilsmeier Chloroformylation

Authors

  • Gareth J. Griffiths

DOI:

https://doi.org/10.2533/chimia.1997.283

Abstract

A novel preparation of 2-butyl-5-chloro-3H-imidazole-4-carbaldehyde, a key intermediate for the synthesis of the angiotensin II antagonist Losartan potassium, via Vilsmeier chloroformylation of imidazolinone is described.

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Published

1997-06-25

Issue

Vol. 51 No. 6 (1997): 100 Years of Progress with Lonza

Section

Scientific Articles

License

Copyright (c) 1997 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
Chimia 1997, 51, 283, DOI: 10.2533/chimia.1997.283.