Homogeneous Catalysis with Metal Complexes in a Pharmaceuticals' and Vitamins' Company: Why, What for, and Where to Go?

Abstract

Homogeneous catalysis with metal complexes is considered a key methodology to become and remain competitive in the manufacture of biologically active molecules and fine chemicals. Opportunities for such methodology will be discussed. Examples of homogeneous catalytic processes developed at Roche are presented, together with a survey of process R&D activities at Roche in this field with special emphasis on enantioselective hydrogenation reactions.