A New Era for Peptide Therapeutics: Innovations, Challenges, and Future Directions

Medicinal Chemistry and Chemical Biology Highlights

Abstract

Peptide drugs are experiencing a renaissance driven by technological breakthroughs and the success of recent blockbuster drugs. A versatile peptide chemistry toolbox, modern synthesis techniques, and powerful discovery platforms are addressing many inherent roadblocks in peptide drug discovery and development allowing complex diseases to be targeted with high specificity and efficacy. As we enter a new era, peptide drugs are well suited to pursue inherently challenging, underrepresented targets and provide innovative treatment options.