Early Assessment of Biodegradability of Small Molecules to Support the Chemical Design in Agro & Pharma R&D

Authors

  • Claudia Coll Soil Health Center, Syngenta Crop Protection, CH-4332 Stein, Switzerland https://orcid.org/0000-0003-1100-1263
  • Kathrin Fenner Chemistry Department, University of Zurich, Zurich; Environmental Chemistry Department, Swiss Federal Institute of Aquatic Science and Technology (Eawag), Dübendorf, Switzerland https://orcid.org/0000-0001-6068-8220
  • Claudio Screpanti Soil Health Center, Syngenta Crop Protection, CH-4332 Stein, Switzerland

DOI:

https://doi.org/10.2533/chimia.2023.742

PMID:

38047841

Keywords:

Active pharmaceutical ingredients, Biodegradability, Green chemistry, Plant protection products, Transformation products

Abstract

The use of agrochemical and pharmaceutical active ingredients is essential in our modern society. Given the increased concern and awareness of the potential risks of some chemicals, there is a growing need to align with ‘green chemistry’ and ‘safe and sustainable by design’ principles and thus to evaluate the hazards of agrochemical and pharmaceutical active ingredients in early stages of R&D. We give an overview of the current challenges and opportunities to assess the principle of biodegradability in the environment. Development of new medium/high-throughput methodologies, combining predictive tools and wet-lab experimentation are essential to design biodegradable chemicals early in the active ingredient discovery and selection process.

Downloads

Published

2023-11-29

Issue

Section

Scientific Articles

How to Cite