Early Assessment of Biodegradability of Small Molecules to Support the Chemical Design in Agro & Pharma R&D
DOI:
https://doi.org/10.2533/chimia.2023.742PMID:
38047841Keywords:
Active pharmaceutical ingredients, Biodegradability, Green chemistry, Plant protection products, Transformation productsAbstract
The use of agrochemical and pharmaceutical active ingredients is essential in our modern society. Given the increased concern and awareness of the potential risks of some chemicals, there is a growing need to align with ‘green chemistry’ and ‘safe and sustainable by design’ principles and thus to evaluate the hazards of agrochemical and pharmaceutical active ingredients in early stages of R&D. We give an overview of the current challenges and opportunities to assess the principle of biodegradability in the environment. Development of new medium/high-throughput methodologies, combining predictive tools and wet-lab experimentation are essential to design biodegradable chemicals early in the active ingredient discovery and selection process.
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Copyright (c) 2023 Claudia Coll, Katrin Fenner, Claudio Screpanti
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This work is licensed under a Creative Commons Attribution 4.0 International License.