Repurposing Know-how for Drug Development: Case Studies from the Swiss Tropical and Public Health Institute
DOI:
https://doi.org/10.2533/chimia.2023.582PMID:
38047834Keywords:
Drug development, Drug discovery, Human African trypanosomiasis, Malaria, Neglected tropical diseases, Product development partnerships, Public-private partnerships, Repurposing know-how, Schistosomiasis, Swiss Tropical and Public Health InstituteAbstract
In pursuing novel therapeutic solutions, drug discovery and development rely on efficiently utilising existing knowledge and resources. Repurposing know-how, a strategy that capitalises on previously acquired information and expertise, has emerged as a powerful approach to accelerate drug discovery and development processes, often at a fraction of the costs of de novo developments. For 80 years, collaborating within a network of partnerships, the Swiss Tropical and Public Health Institute (Swiss TPH) has been working along a value chain from innovation to validation and application to combat poverty-related diseases. This article presents an overview of selected know-how repurposing initiatives conducted at Swiss TPH with a particular emphasis on the exploration of drug development pathways in the context of neglected tropical diseases and other infectious diseases of poverty, such as schistosomiasis, malaria and human African trypanosomiasis.
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Copyright (c) 2023 Lukas Meier, Marina Antillon, Christian Burri, Nakul Chitnis, Yvette Endriss, Jennifer Keiser, Sarah Moore, Pie Müller, Melissa Penny, Till S. Voss, Pascal Mäser, Jürg Utzinger
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This work is licensed under a Creative Commons Attribution 4.0 International License.