Enantioselective Switch and Potential Applications in Biocatalysis
DOI:
https://doi.org/10.2533/chimia.2023.390PMID:
38047778Keywords:
Biocatalysis, Enantiopreference, Enzymes, TransaminaseAbstract
Enantioselectivity has always been a key feature of enzymatic synthesis. In some cases, when enzymes are not strictly enantioselective, by tuning the reaction conditions it is possible to induce an enantioselective switch. A transaminase from Halomonas elongata (ω-HeWT), while generally S-selective, could be shifted towards generating the R-enantiomer at higher concentrations of amino acceptor or ionic strength, for example. Other enzymes are reported to have a similar behavior, and here we discuss some of them and their potential applications.
Funding data
-
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Grant numbers 200021_192274
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Published
2023-06-28
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Scientific Articles
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Copyright (c) 2023 Lucia Robustini, Francesca Paradisi
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This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
[1]
Chimia 2023, 77, 390, DOI: 10.2533/chimia.2023.390.