Evolution of Solid Processing Methods in Continuous Flow Technology: Reactive Extrusion

Authors

  • Jamie A. Leitch Department of Pharmaceutical and Biological Chemistry, UCL, School of Pharmacy, 29-39 Brunswick Square, Bloomsbury, London, WC1N 1AX https://orcid.org/0000-0001-6997-184X
  • Paul Richardson Pfizer Inc., 10555 Science Center Drive, San Diego, CA92121
  • Duncan L. Browne Department of Pharmaceutical and Biological Chemistry, UCL, School of Pharmacy, 29-39 Brunswick Square, Bloomsbury, London, WC1N 1AX

DOI:

https://doi.org/10.2533/chimia.2023.339

PMID:

38047830

Keywords:

Continuous Flow, Extrusion, Mechanochemistry, Solids

Abstract

The frustrations of precipitation, fouling and blockages of liquid-based flow reactors is familiar to all researchers that have worked with continuous flow equipment. There have been many innovative solutions to try and circumvent this issue. This short review will highlight the emerging technique of mechanochemistry and reactive extrusion as a continuous process that can directly work on solid (and liquid) materials and elicit chemical transformations.

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Published

2023-05-31

Issue

Vol. 77 No. 5 (2023): The Evolution of Flow Chemistry

Section

Scientific Articles

License

Copyright (c) 2023 J. A. Leitch, P. Richardson, D. L. Browne

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
J. A. Leitch, P. Richardson, D. L. Browne, Chimia 2023, 77, 339, DOI: 10.2533/chimia.2023.339.