Going with the µFlow: Reinterpreting Energy Input in Organic Synthesis

Authors

  • Laura Y. Vázquez-Amaya Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001, Leuven
  • Guglielmo A. Coppola Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001, Leuven
  • Erik V. Van der Eycken Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001, Leuven, Belgium; Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow 117198, Russia
  • Upendra K. Sharma Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001, Leuven, Belgium

DOI:

https://doi.org/10.2533/chimia.2023.327

PMID:

38047829

Keywords:

Enabling technologies, Electrochemistry, Hydrodynamic cavitation, Microfluidics, Microfluidics plasma, Microsynthesis, Microwave, Photochemistry, Process intensification technology, Ultrasound

Abstract

The popularity of microflow chemistry has skyrocketed in the last 20 years, more and more chemists are switching from macro-batch reactors to miniaturized flow devices. As a result, microfluidics is paving its way into the future by consolidating its position in organic chemistry not only as a trend but as a new, effective, and sustainable way of conducting chemistry, that clearly will continue to grow and evolve. This perspective highlights the most relevant examples of innovative enhancing technologies applied to microflow reactors aimed to improve and intensify chemical processes. The extensive applicability of microflow chemistry is further illustrated by briefly discussing examples of complex integrated microsystems and scale-up technologies, demonstrating ultimately that microflow chemistry has the potential to become the ideal technology for the future.

Funding data

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Published

2023-05-31

Issue

Vol. 77 No. 5 (2023): The Evolution of Flow Chemistry

Section

Scientific Articles

License

Copyright (c) 2023 Laura Y. Vázquez-Amaya, Guglielmo A. Coppola, Erik V. Van der Eycken, Upendra K. Sharma

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
L. Y. Vázquez-Amaya, G. A. Coppola, E. V. Van der Eycken, U. K. Sharma, Chimia 2023, 77, 327, DOI: 10.2533/chimia.2023.327.