Medicinal Chemistry of Oligonucleotide Drugs - Milestones of the Past and Visions for the Future
DOI:
https://doi.org/10.2533/chimia.2022.466PMID:
38069719Keywords:
Antisense, Gapmer, Oligonucleotide, Small interfering RNAAbstract
The oligonucleotide therapeutics field has blossomed in recent years, with thirteen approved drugs today and the promise of accelerated growth in coming years. Much of the progress in this field is due to advances in the medicinal chemistry of oligonucleotides,combined with a judicious choice of molecular targets and disease areas. In this perspective, we describe the growth of this new class of drugs highlighting selected milestones in oligonucleotide medicinal chemistry.
Funding data
-
Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Grant numbers 182880
Downloads
Published
2022-05-25
Issue
Section
Scientific Articles
License
Copyright (c) 2022 Jonathan Hall, Anastasia Ashkinadze, Jan Philipp Becker, Artur Laski, Eva-Maria Manz, Štefan Moravčík, Sebastian Sjöström, Mathilde Vincent
![Creative Commons License](http://i.creativecommons.org/l/by/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
[1]
J. Hall, A. Ashkinadze, J. P. Becker, A. Laski, E.-M. Manz, Štefan Moravčík, S. Sjöström, M. Vincent, Chimia 2022, 76, 466, DOI: 10.2533/chimia.2022.466.