Hyperpolarized Solvatochromic Nanosensors towards Heparin Sensing in Blood
Keywords:Agarose, Heparin, Nanoparticles, Protamine, Solvatochromism
Heparin quantification at the point of care has been of medical interest for years but a suitable point of care measurement method for whole blood is still elusive. Our group has recently developed a nanoparticle-based optical sensor for protamine that allows for heparin quantification in plasma. This work discusses the effect of the transducing-dye structure and the promise of embedding the sensors in an agarose gel for avoiding red blood cell interference.
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