Hyperpolarized Solvatochromic Nanosensors towards Heparin Sensing in Blood

Authors

  • Robin Nussbaum Dept. Inorganic and Analytical Chemistry, University of Geneva, Geneva, CH-1205 Geneva
  • Kye J. Robinson Dept. Inorganic and Analytical Chemistry, University of Geneva, Geneva, CH-1205 Geneva https://orcid.org/0000-0003-2710-4718
  • Yoshiki Soda Dept. Inorganic and Analytical Chemistry, University of Geneva, Geneva, CH-1205 Geneva
  • Eric Bakker Dept. Inorganic and Analytical Chemistry, University of Geneva, Geneva, CH-1205 Geneva https://orcid.org/0000-0001-8970-4343

DOI:

https://doi.org/10.2533/chimia.2022.284

PMID:

38069764

Keywords:

Agarose, Heparin, Nanoparticles, Protamine, Solvatochromism

Abstract

Heparin quantification at the point of care has been of medical interest for years but a suitable point of care measurement method for whole blood is still elusive. Our group has recently developed a nanoparticle-based optical sensor for protamine that allows for heparin quantification in plasma. This work discusses the effect of the transducing-dye structure and the promise of embedding the sensors in an agarose gel for avoiding red blood cell interference.

CHIMIA Vol. 76 No. 4 (2022): Laureates: Junior Prizes of the SCS Fall Meeting 2021

Downloads

Additional Files

Published

2022-04-27

Issue

Vol. 76 No. 4 (2022): Laureates: Junior Prizes of the SCS Fall Meeting 2021

Section

Scientific Articles

License

Copyright (c) 2022 Robin Nussbaum, Kye J. Robinson, Yoshiki Soda, Eric Bakker

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

[1]
R. Nussbaum, K. Robinson, Y. Soda, E. Bakker, Chimia 2022, 76, 284, DOI: 10.2533/chimia.2022.284.