Hyperpolarized Solvatochromic Nanosensors towards Heparin Sensing in Blood

Authors

  • Robin Nussbaum Dept. Inorganic and Analytical Chemistry, University of Geneva, Geneva, CH-1205 Geneva
  • Kye J. Robinson Dept. Inorganic and Analytical Chemistry, University of Geneva, Geneva, CH-1205 Geneva https://orcid.org/0000-0003-2710-4718
  • Yoshiki Soda Dept. Inorganic and Analytical Chemistry, University of Geneva, Geneva, CH-1205 Geneva
  • Eric Bakker Dept. Inorganic and Analytical Chemistry, University of Geneva, Geneva, CH-1205 Geneva https://orcid.org/0000-0001-8970-4343

DOI:

https://doi.org/10.2533/chimia.2022.284

Keywords:

Agarose, Heparin, Nanoparticles, Protamine, Solvatochromism

Abstract

Heparin quantification at the point of care has been of medical interest for years but a suitable point of care measurement method for whole blood is still elusive. Our group has recently developed a nanoparticle-based optical sensor for protamine that allows for heparin quantification in plasma. This work discusses the effect of the transducing-dye structure and the promise of embedding the sensors in an agarose gel for avoiding red blood cell interference.

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Published

2022-04-27

How to Cite

[1]
R. Nussbaum, K. Robinson, Y. Soda, E. Bakker, Chimia 2022, 76, 284, DOI: 10.2533/chimia.2022.284.