Targeting Ion Channel TRPM4
Keywords:Cancer, Cardiac disease, TRPM4, Small-molecule inhibitors
The transient receptor potential melastatin 4 (TRPM4) ion channel is ubiquitously expressed. Dysregulation and/or functional mutations of TRPM4 lead to several diseases. Within our studies, we screened for TRPM4 inhibitors and identified small molecules that block TRPM4 in the low µM range. Furthermore, we investigated the pathophysiology of TRPM4 in cardiac conditions, immune diseases and cancer using these novel inhibitors, molecular biology techniques and functional assays.
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Copyright (c) 2022 Christine Peinelt, Barbara Preti, Jean-Sébastien Rougier, Irida Papapostolou, Florian Bochen, Christian Elias Gerber, Hugues Abriel, Martin Lochner
This work is licensed under a Creative Commons Attribution 4.0 International License.