Heterogeneous Metal-Organic Framework Catalysts for Suzuki-Miyaura Cross Coupling in the Pharma Industry
Keywords:Metal-organic framework, Suzuki-Miyaura Cross Coupling, Catalysis, Pharma Industry, Sustainable organic processes
The synthesis of drug substances (DS) requires the continuous effort of the pharma industry to ensure high sustainability standards. Suzuki Miyaura cross coupling is a fundamental C-C bond-forming reaction to produce complex DS intermediates. The present contribution points out the way, in which the synthesis of DS intermediates by C-C cross coupling can be economically competitive, while minimizing waste by selecting the appropriate heterogeneous catalyst. By comparing homogeneous, immobilized heterogeneous catalysts on silica and metal-organic framework (MOF) catalysts, while considering the perspectives of academia and industry, the critical parameters for a successful industrial application of heterogeneous catalytic Suzuki Miyaura cross coupling reactions were identified. Heterogeneous catalysts, such as MOFs, may provide the complementary platform for reducing waste and the costs of production related to such transformations.
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Copyright (c) 2021 Marco Ranocchiari, Daniele Cartagenove, Stephan Bachmann, Kurt Püntener, Jeroen Anton van Bokhoven
This work is licensed under a Creative Commons Attribution 4.0 International License.