From Academia to the Market – Air-stable Ni(II)/Josiphos Catalysts

Authors

  • Florian Bächle Solvias AG, Römerpark 2, CH-4303 Kaiseraugst
  • Achim Link Solvias AG, Römerpark 2, CH-4303 Kaiseraugst https://orcid.org/0000-0001-5390-6656
  • Abderrahmane Amgoune Institute of Chemistry and Biochemistry (ICBMS–UMR CNRS 5246), Univ Lyon, Université Lyon 1, CNRS, CPE-Lyon, INSA, 43 Bd du 11 Novembre 1918, 69622 Villeurbanne https://orcid.org/0000-0002-6195-1411
  • Anis Tlili Institute of Chemistry and Biochemistry (ICBMS–UMR CNRS 5246), Univ Lyon, Université Lyon 1, CNRS, CPE-Lyon, INSA, 43 Bd du 11 Novembre 1918, 69622 Villeurbanne https://orcid.org/0000-0002-3058-2043

DOI:

https://doi.org/10.2533/chimia.2021.943

Keywords:

Nickel, Josiphos, Monoarylation, Ammonia, Acetone, Catalysis

Abstract

The design, synthesis, commercialization and application of air stable Ni(II)/Josiphos complexes has been realized in a collaboration between Solvias and ICBMS (University Lyon 1). The Ni-complexes  are utilized as versatile precatalysts for diverse cross coupling reactions. Apart from being active in established C–C and C–N couplings at low catalyst loadings, the novel Ni-precatalysts enabled the development of the challenging monoarylation of ammonia, ammonia surrogates and even alkylammonium chlorides with aryl carbamates. Finally, the alpha-arylation of acetone with aryl chlorides, carbamates and pivalates was demonstrated using the Ni(II)/Josiphos precatalysts.

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Published

2021-11-11

How to Cite

[1]
F. Bächle, A. Link, A. Amgoune, A. Tlili, Chimia 2021, 75, 943, DOI: 10.2533/chimia.2021.943.