Recent Developments and Aspects of Industrial Fluoroalkylation

Abstract

Fluoroalkylations have received increasing attention in the academic and industrial environment due to the particular properties of the active ingredients, strongly influenced by fluoroalkyl substituents. The inherent difficulties of introducing a fluoroalkyl substituent into advanced intermediates has triggered the development of an enormous number of specialized reagents, which, however, are often not suitable for large scale applications. In contrast to this reagent based fluoroalkylation approach, the direct activation of industrially readily available fluoroalkyl halides could be more suitable for a large-scale processes. In this way the dithionite initiated fluoroalkylation as well as newly developed catalytic activated fluoroalkylation protocols were considered for industrial large-scale applications.