Macrocycle Therapeutics to Treat Life-threatening Diseases
Keywords:Antibiotic, Breast cancer, Cxcr4 inhibitor, Macrocycle, Protein epitope mimetic
AbstractPolyphor's macrocycle platform led to the discovery of novel antibiotics addressing specifically Gramnegative bacteria by targeting outer membrane proteins. Furthermore, POL6014, an inhibitor of neutrophile elastase and balixafortide, a CXCR4 inhibitor have been discovered and developed from the platform. Currently a combination of balixafortide and eribulin is in Phase III clinical trial for the treatment of patients with advanced metastatic HER2-negative breast cancer.
How to Cite
G. Batur, P. Ermert, J. Zimmermann, D. Obrecht, Chimia 2021, 75, 508, DOI: 10.2533/chimia.2021.508.
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