DNA-tethered Polymersome Clusters as Nanotheranostic Platform

Authors

  • Claire E. Meyer Department of Chemistry, University of Basel, Mattenstrasse 24a, CH-4002 Basel, Switzerland
  • Cora-Ann Schoenenberger Department of Chemistry, University of Basel, Mattenstrasse 24a, CH-4002 Basel, Switzerland
  • Juan Liu Department of Chemistry, University of Basel, Mattenstrasse 24a, CH-4002 Basel, Switzerland
  • Ioana Craciun Department of Chemistry, University of Basel, Mattenstrasse 24a, CH-4002 Basel, Switzerland
  • Cornelia G. Palivan Department of Chemistry, University of Basel, Mattenstrasse 24a, CH-4002 Basel, Switzerland;, Email: cornelia.palivan@unibas.ch

DOI:

https://doi.org/10.2533/chimia.2021.296

Keywords:

Cluster, Dna tethering, Enzymes, Nanotheranostics, Polymersome

Abstract

Nanotheranostics combine the use of nanomaterials and biologically active compounds to achieve diagnosis and treatment at the same time. To date, severe limitations compromise the use of nanotheranostic systems as potent nanomaterials are often incompatible with potent biomolecules. Herein we emphasize how a novel type of polymersome clusters loaded with active molecules can be optimized to obtain an efficient nanotheranostic platform. Polymersomes loaded with enzymes and specific dyes, respectively and exposing complementary DNA strands at their external surface formed clusters by means of DNA hybridization. We describe factors at the molecular level and other conditions that need to be optimized at each step of the cluster formation to favor theranostic efficiency.

Downloads

Published

2021-04-28

How to Cite

[1]
C. E. Meyer, C.-A. Schoenenberger, J. Liu, I. Craciun, C. G. Palivan, Chimia 2021, 75, 296, DOI: 10.2533/chimia.2021.296.