Pushing the Frontiers of Accessible Chemical Space to Unleash Design Creativity and Accelerate Drug Discovery

Authors

  • Thomas C. Fessard SpiroChem AG, Mattenstrasse 24, CH-4058 Basel, Switzerland;, Email: thomas.fessard@spirochem.ch
  • Kristina Goncharenko SpiroChem AG, Mattenstrasse 24, CH-4058 Basel, Switzerland
  • Quentin Lefebvre SpiroChem AG, Mattenstrasse 24, CH-4058 Basel, Switzerland
  • Christophe Salomé SpiroChem AG, Mattenstrasse 24, CH-4058 Basel, Switzerland

DOI:

https://doi.org/10.2533/chimia.2020.803

Keywords:

C–h activation, Late-stage functionalization, Synthetic efficiency, Sp3 scaffolds

Abstract

In highly competitive research environments, the ability to access more complex structural spaces efficiently is a predictor of a company's ability to generate novel IP-protected small molecule candidates with adequate properties, hence filling their development pipelines. SpiroChem is consistently developing new synthetic methodologies and strategies to access complex molecular structure, thereby facilitating and accelerating small molecule drug discovery. Pushing the limits of what are perceived as complex molecular structures allows SpiroChem and its clients to unleash creativity and explore meaningful chemical spaces, which are under-exploited sources of novel active molecules. In this article, we explain how we differentiated ourselves in a globalized R&D environment and we provide several snapshots of how efficient methodologies can generate complex structures, rapidly.

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Published

2020-10-28

How to Cite

[1]
T. C. Fessard, K. Goncharenko, Q. Lefebvre, C. Salomé, Chimia 2020, 74, 803, DOI: 10.2533/chimia.2020.803.