Bioinspired Non-Heme Iron Complexes: The Evolution of Facial N, N, O Ligand Design

Authors

  • Emily C. Monkcom Utrecht University, Organic Chemistry & Catalysis, Debye Institute for Nanomaterials Science, Faculty of Science, 3584 CG Utrecht, The Netherlands
  • Pradip Ghosh Utrecht University, Organic Chemistry & Catalysis, Debye Institute for Nanomaterials Science, Faculty of Science, 3584 CG Utrecht, The Netherlands
  • Emma Folkertsma Utrecht University, Organic Chemistry & Catalysis, Debye Institute for Nanomaterials Science, Faculty of Science, 3584 CG Utrecht, The Netherlands
  • Hidde A. Negenman Utrecht University, Organic Chemistry & Catalysis, Debye Institute for Nanomaterials Science, Faculty of Science, 3584 CG Utrecht, The Netherlands
  • Martin Lutz Utrecht University, Crystal and Structural Chemistry, Bijvoet Centre for Biomolecular Research, Faculty of Science, 3584 CH Utrecht, The Netherlands
  • Robertus J. M. Klein Gebbink Utrecht University, Organic Chemistry & Catalysis, Debye Institute for Nanomaterials Science, Faculty of Science, 3584 CG Utrecht, The Netherlands;, Email: r.j.m.kleingebbink@uu.nl

DOI:

https://doi.org/10.2533/chimia.2020.450

PMID:

32560750

Keywords:

Bioinspired metal complexes, 2-his-1-carboxylate facial triad, N,n,o ligands, Non-heme iron

Abstract

Iron-containing metalloenzymes that contain the 2-His-1-Carboxylate facial triad at their active site are well known for their ability to activate molecular oxygen and catalyse a broad range of oxidative transformations. Many of these reactions are synthetically challenging, and developing small molecular iron-based catalysts that can achieve similar reactivity and selectivity remains a long-standing goal in homogeneous catalysis. This review focuses on the development of bioinspired facial N,N,O ligands that model the 2-His-1-Carboxylate facial triad to a greater degree of structural accuracy than many of the polydentate N-donor ligands commonly used in this field. By developing robust, well-defined N,N,O facial ligands, an increased understanding could be gained of the factors governing enzymatic reactivity and selectivity.

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Published

2020-06-24

How to Cite

[1]
E. C. Monkcom, P. Ghosh, E. Folkertsma, H. A. Negenman, M. Lutz, R. J. M. Klein Gebbink, Chimia 2020, 74, 450, DOI: 10.2533/chimia.2020.450.