Recent Advances in Mode of Action and Biosynthesis Studies of the Clinically Used Antibiotic Fidaxomicin

Authors

  • Andrea Dorst University of Zurich, Department of Chemistry, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
  • Erik Jung University of Zurich, Department of Chemistry, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
  • Karl Gademann University of Zurich, Department of Chemistry, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland;, Email: karl.gademann@chem.uzh.ch

DOI:

https://doi.org/10.2533/chimia.2020.270

PMID:

32331545

Keywords:

Antibiotics, Biosynthesis, Mode of action, Natural products, Sar studies

Abstract

The natural product antibiotic fidaxomicin is a marketed drug for the treatment of bacterial infections in the gut. Due to its promising in vitro activities against Mycobacterium tuberculosis, the development of next generation fidaxomicin analogs is of great interest. This article reviews the most recent advances, including the elucidation of a unique mode of action by cryo-EM structures, and the efforts towards the clarification of the biosynthetic pathway. Moreover, known fidaxomicin analogs and their reported antibacterial activities are summarized.
CHIMIA Vol. 74 No. 04(2020): Laureates: Junior Prizes of the SCS Fall Meeting 2019

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Published

2020-04-29

Issue

Vol. 74 No. 4 (2020): Laureates: Junior Prizes of the SCS Fall Meeting 2019

Section

Scientific Articles

License

Copyright (c) 2020 Andrea Dorst, Erik Jung, Karl Gademann

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
A. Dorst, E. Jung, K. Gademann, Chimia 2020, 74, 270, DOI: 10.2533/chimia.2020.270.