The Xanthate Route to Amino Acids

Abstract

The degenerative xanthate addition transfer to alkenes allows the synthesis of a broad range of protected, and in some cases enantiopure, ?, ?, and ?-amino acids, including proline and pipecolic derivatives, as well as fluorinated congeners and ?-lactams. The radical addition furnishes naturally latent mercapto-?-amino acids that are ideally equipped for native chemical ligation. Most of the amino acid structures accessible rapidly by this chemistry would otherwise require tedious multi-step syntheses.