A Hybridised Optimisation of an Automated Photochemical Continuous Flow Reactor

Authors

  • Jamie A. Manson
  • Adam D. Clayton
  • Carlos Gonzalez Niño
  • Ricardo Labes
  • Thomas W. Chamberlain
  • A. John Blacker
  • Nikil Kapur
  • Richard A. Bourne

DOI:

https://doi.org/10.2533/chimia.2019.817

PMID:

31645242

Keywords:

Algorithm, Automation, Continuous flow, Photochemistry, Self-optimisation

Abstract

A new hybridized algorithm that combines process optimisation with response surface mapping was developed and applied in an automated continuous flow reaction. Moreover, a photochemical cascade CSTR was developed and characterised by chemical actinometry, showing photon flux density of ten times greater than previously reported in batch. The success of the algorithm was then evaluated in the aerobic oxidation of sp3 C–H bonds using benzophenone as photosensitizer in the newly developed photo reactor.
CHIMIA Vol. 73 No. 10(2019): Continuous Flow Chemistry – Industry and Academia Perspectives

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Published

2019-10-30

Issue

Vol. 73 No. 10 (2019): Continuous Flow Chemistry – Industry and Academia Perspectives

Section

Scientific Articles

License

Copyright (c) 2019 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
J. A. Manson, A. D. Clayton, C. G. Niño, R. Labes, T. W. Chamberlain, A. J. Blacker, N. Kapur, R. A. Bourne, Chimia 2019, 73, 817, DOI: 10.2533/chimia.2019.817.