Effect of Clustering on the Heat Generated by Superparamagnetic Iron Oxide Nanoparticles

Abstract

Magnetic nanoparticles have been the subject of enormous investigations for their potential use as cancer treatment via hyperthermia. This is due to their ability to generate heat when exposed to an external magnetic field oscillating at sufficiently high frequency. There are many different parameters that need to be considered when designing the optimal nanoparticle formulation for hyperthermia. The effect of the formation of clusters of nanoparticles, which is either an unwanted side effect of poor colloidal stability of the particles, or a desired formulation strategy, has poorly understood consequences on the amount of heat generated by the nanoparticles. The objective of this work is to address this problem from the theoretical side by performing detailed simulations to investigate the effect of incorporation of magnetic nanoparticles in clusters on the amount of heat generated as a function of the particle size, cluster size and particles magnetic properties.