Recent Developments and Applications of Photoconjugation Chemistry

Authors

  • Fan Xiao Department of Chemical Biology College of Chemistry and Molecular Engineering Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education Synthetic and Functional Biomolecules Center and Peking-Tsinghua Center for Life Sciences Peking University, Beijing 100871, China
  • Xiaoyun Zhang Department of Chemical Biology College of Chemistry and Molecular Engineering Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education Synthetic and Functional Biomolecules Center and Peking-Tsinghua Center for Life Sciences Peking University, Beijing 100871, China
  • Xiaoguang Lei Department of Chemical Biology College of Chemistry and Molecular Engineering Beijing National Laboratory for Molecular Sciences Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education Synthetic and Functional Biomolecules Center and Peking-Tsinghua Center for Life Sciences Peking University, Beijing 100871, China. xglei@pku.edu.cn

DOI:

https://doi.org/10.2533/chimia.2018.782

Keywords:

Bioorthogonal ligation, Chemical biology, Photoconjugation, Small molecule probe

Abstract

Understanding of biological systems has always been the general interest in chemical biology, and chemical modifications of biomolecules are often required to elucidate their functions and properties. There has thus been a rapid development of covalent chemistries for the modification of macromolecules. Among these strategies, photochemistry provides the advantage of using biocompatible light as an energy source to trigger bioconjugation reactions; this circumvents the use of toxic reagents (e.g. metal catalysts and chelating ligands). Light-induced chemistry can achieve precise spatial and temporal conjugation of biomolecules in their native environment.

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Published

2018-11-30

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Scientific Articles