Recent Development of Photo-Cross-Linkers as Tools for Biomedical Research

Authors

  • Yulin Tian 679 Natural Science Complex Department of Chemistry State University of New York at Buffalo Buffalo, New York 14260, USA
  • Qing Lin 679 Natural Science Complex Department of Chemistry State University of New York at Buffalo Buffalo, New York 14260, USA. qinglin@buffalo.edu

DOI:

https://doi.org/10.2533/chimia.2018.758

Keywords:

Genetic encoding, Photo-affinity probe, Photo-cross-linker, Protein–protein interaction, Target identification

Abstract

Photo-cross-linkers are invaluable tools for identifying drug targets and off-targets as well as probing the binding sites in medicinal chemistry and chemical biology. In this review, we summarize recent development of the ligand-based and genetically encoded photo-cross-linkers and their use in biological system. In particular, we highlight our discovery of 2-aryl-5-carboxytetrazole (ACT) as a novel class of photo-cross-linkers and their successful applications in drug target identification as well as identifying transient protein–protein interaction complexes in mammalian cells.
CHIMIA Vol. 72 No. 11(2018): Bioorthogonal Chemistry

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Published

2018-11-30

Issue

Vol. 72 No. 11 (2018): Bioorthogonal Chemistry

Section

Scientific Articles

License

Copyright (c) 2018 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
Y. Tian, Q. Lin, Chimia 2018, 72, 758, DOI: 10.2533/chimia.2018.758.