Synergistic Action of Copper Catalysts and Lewis Acids in Carbon–Carbon Bond Forming Reactions

Authors

  • Manas Das Synthetic Organic Chemistry Stratingh Institute for Chemistry University of Groningen Nijenborgh 4, Groningen, Netherlands
  • Syuzanna Harutyunyan Synthetic Organic Chemistry Stratingh Institute for Chemistry University of Groningen Nijenborgh 4, Groningen, Netherlands;, Email: s.harutyunyan@rug.nl

DOI:

https://doi.org/10.2533/chimia.2018.642

Keywords:

Alkylation, Asymmetric catalysis, Copper, Grignard reagents, Lewis acid

Abstract

Combining Lewis acids with copper catalysis and highly reactive Grignard reagents allows fine tuning of the reactivity and selectivity of both inherently unreactive and highly reactive electrophilic substrates in asymmetric C–C bond forming reactions. In this review we will discuss various examples where the application of this strategy provides access to efficient catalytic processes for the synthesis of chiral molecules such as alcohols, amides and heteroarenes.
CHIMIA Vol. 72 No. 9 (2018): Organometallics and Catalysis

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Published

2018-09-01

Issue

Vol. 72 No. 9 (2018): Organometallics and Catalysis

Section

Scientific Articles

License

Copyright (c) 2018 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
M. Das, S. Harutyunyan, Chimia 2018, 72, 642, DOI: 10.2533/chimia.2018.642.