Catalytic Arene-forming Aldol Condensation: Stereoselective Synthesis of Rotationally Restricted Aromatic Compounds
DOI:
https://doi.org/10.2533/chimia.2017.596Keywords:
Aldol condensation, Arylenes, Atropisomers, Axial chirality, Stereoselective catalysisAbstract
By taking inspiration from the fascinating biosynthetic machinery that creates aromatic polyketides, our group investigates analogous reactions catalyzed by small molecules. We are particularly captivated by the prospects of intramolecular aldol condensation reactions to generate different rotationally restricted aromatic compounds. In a first project of our independent research group, a highly stereoselective amine catalyzed synthesis of axially chiral biaryls, tertiary aromatic amides and oligo-1,2-naphthylenes has been developed. In this article, we outline the twists and turns for our escape from the aromatic flatland to structurally intriguing chiral arene scaffolds relevant for various fields of application.Downloads
Published
2017-09-27
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Scientific Articles
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Copyright (c) 2017 Swiss Chemical Society
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How to Cite
[1]
V. C. Fäseke, R. M. Witzig, A. Link, D. Lotter, C. Sparr, Chimia 2017, 71, 596, DOI: 10.2533/chimia.2017.596.