Arene Ruthenium(II) Complexes with Phosphorous Ligands as Possible Anticancer Agents

Authors

  • Lorenzo Biancalana University of Pisa Dipartimento di Chimica e Chimica Industriale Via Moruzzi 13, I-56124 Pisa, Italy
  • Guido Pampaloni University of Pisa Dipartimento di Chimica e Chimica Industriale Via Moruzzi 13, I-56124 Pisa, Italy
  • Fabio Marchetti University of Pisa Dipartimento di Chimica e Chimica Industriale Via Moruzzi 13, I-56124 Pisa, Italy. fabio.marchetti1974@unipi.it

DOI:

https://doi.org/10.2533/chimia.2017.573

Keywords:

Anticancer drugs, Bioactive groups, Phosphorus ligand, Rapta, Ruthenium arene compounds

Abstract

Ruthenium(II) complexes of formula [Ru(?6-arene)Cl2 (PTA)] (RAPTA) are potential anticancer drugs with notable antimetastatic and antiangiogenic activity, which are now pointing to clinical trials. Following the great interest aroused by these compounds, a variety of RAPTA derivatives, obtained by chloride substitution and/or containing functionalized arene ligands, and complexes resembling the RAPTA structure but bearing different phosphorous ligands have been synthesized and evaluated for their anticancer activity. An overview of all of these biologically relevant complexes will be given, with particular reference to the anticancer behaviour exhibited by the compounds and the possible relationship with structural aspects.
CHIMIA Vol. 71 No. 09(2017): Italian Connections

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Published

2017-09-27

Issue

Vol. 71 No. 9 (2017): Italian Connections

Section

Scientific Articles

License

Copyright (c) 2017 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
L. Biancalana, G. Pampaloni, F. Marchetti, Chimia 2017, 71, 573, DOI: 10.2533/chimia.2017.573.