Engineering Nanosized Organosilica for Molecular Recognition and Biocatalysis Applications

FH-HES Universities of Applied Sciences

Authors

  • M. Rita Correro University of Applied Sciences and Arts Northwestern Switzerland, School of Life Sciences, Institute of Chemistry and Bioanalytics, Gründenstrasse 40, CH-4132 Muttenz, Switzerland
  • Yves Dudal INOFEA AG, Hochbergerstasse 60c, CH-4057 Basel, Switzerland
  • Philippe F.-X. Corvini University of Applied Sciences and Arts Northwestern Switzerland, School of Life Sciences, Institute of Chemistry and Bioanalytics, Gründenstrasse 40, CH-4132 Muttenz, Switzerland
  • Patrick Shahgaldian University of Applied Sciences and Arts Northwestern Switzerland, School of Life Sciences, Institute of Chemistry and Bioanalytics, Gründenstrasse 40, CH-4132 Muttenz, Switzerland. patrick.shahgaldian@fhnw.ch

DOI:

https://doi.org/10.2533/chimia.2017.243

Keywords:

Molecular recognition, Nanobiocatalysts, Nanoparticles, Organosilica, Self-assembly

Abstract

A series of synthetic nanomaterials capable of molecular recognition and/or biocatalysis have been produced by exploiting the self-sorting, self-assembly and polycondensation of organosilane building blocks around protein templates. The established methodology allows for the production of thin organosilica layers of controlled thickness, down to nanometer precision. Fully synthetic virus recognition materials have been shown to specifically bind their target virus down to picomolar concentrations. The shielding of natural enzymes allowed producing nanobiocatalysts functioning under harsh operational conditions.

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Published

2017-04-26

How to Cite

[1]
M. R. Correro, Y. Dudal, P. F.-X. Corvini, P. Shahgaldian, Chimia 2017, 71, 243, DOI: 10.2533/chimia.2017.243.