Towards Cellular Activation of an Artificial Metalloenzyme: Development of an Artificial Zymogen

Authors

  • Vincent Lebrun Department of Chemistry University of Basel CH-4056 Basel, Switzerland. vincent.lebrun@unibas.ch

DOI:

https://doi.org/10.2533/chimia.2017.199

Keywords:

Artificial metalloenzyme, Catalysis, Cross regulation, Transfer hydrogenation, Zymogen

Abstract

Regulation of enzymatic activity is essential for living organisms. Nowadays, with the emergence of synthetic biology, there is a rising interest in placing the activity of synthetic catalysts under the control of a cell. This short review aims at summarizing the regulation strategies developed to date, and at presenting the development of an artificial zymogen, which is upregulated by a natural protease. In our view, this constitutes a first step towards the cellular control of the activity of an artificial metalloenzyme.

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Published

2017-04-26

How to Cite

[1]
V. Lebrun, Chimia 2017, 71, 199, DOI: 10.2533/chimia.2017.199.