Automated Microscopy and High Content Screens (Phenotypic Screens) in Academia Labs
Keywords:High-content screening, Image-based screening
AbstractImaged-based screening has been developing extremely quickly in the past 10 years. Academic institutes quickly realized that the discovery capacity of this technology was huge, allowing the automatic detection and quantification of complex cell phenotypes. Associated with chemical or genetic perturbations, high content screening is the method of choice for a deep system biology analysis. The evolution of high-content screening is mainly due to the recent progress in the development of fast and high quality automated imagers and of a plethora of new very bright fluorescent markers, so that almost any cellular element can be seen and imaged. In this paper we review and summarize the major steps in the development of an image-based screening project.
How to Cite
D. Moreau, J. Gruenberg, Chimia 2016, 70, 878, DOI: 10.2533/chimia.2016.878.
Copyright (c) 2016 Swiss Chemical Society
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