Contributions of Biomolecular NMR to Allosteric Drug Discovery

Lukasz Skora; Wolfgang Jahnke

doi:10.2533/chimia.2015.421

Contributions of Biomolecular NMR to Allosteric Drug Discovery

Authors

Lukasz Skora Novartis Institutes for Biomedical Research, Novartis Campus, CH-4002 Basel, Switzerland
Wolfgang Jahnke Novartis Institutes for Biomedical Research, Novartis Campus, CH-4002 Basel, Switzerland. wolfgang.jahnke@novartis.com

DOI:

https://doi.org/10.2533/chimia.2015.421

Keywords:

Allosteric drug discovery, Biomolecular nmr

Abstract

Drug discovery is a complex process, and a variety of technologies contribute to its success. Biophysical methods have gained widespread attention within the last decade, and in particular NMR spectroscopy as the most versatile biophysical method has seen numerous applications and significant impact to drug discovery. Here we summarize the potential of NMR to support drug discovery, and highlight a number of recent applications.