Transition Metal-free Methylation of Amines with Formaldehyde as the Reductant and Methyl Source
Keywords:Anilines, Eschweiler-clarke reaction, Formaldehyde, Metal-free, N-methylation
AbstractA simple transition metal-free procedure using formal dehyde for the N,N-dimethylation and N-methylation of primary and secondary anilines is reported. The reaction showed limitations on sterically hindered and electron-withdrawing anilines, but is successful on amines with electron-donating substituents. Formaldehyde acts as both the reducing agent and the carbon source in the reaction.
How to Cite
N. Y. T. Man, W. Li, S. G. Stewart, X.-F. Wu, Chimia 2015, 69, 345, DOI: 10.2533/chimia.2015.345.
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