Platinum(IV) Carboxylate Prodrug Complexes as Versatile Platforms for Targeted Chemotherapy
DOI:
https://doi.org/10.2533/chimia.2015.100Keywords:
Anticancer, Cisplatin, Oxaliplatin, Platinum(iv) prodrugs, Targeted chemotherapyAbstract
Kinetically-inert Pt(IV) carboxylate complexes have emerged in recent years as candidates for the development of next-generation platinum anticancer drugs. Being native prodrugs of clinically-important Pt(II) chemotherapeutic agents, the Pt(IV) scaffold can be exploited to incorporate additional functionalities while keeping the Pt(II) pharmacophore intact. This mini-review examines recent work performed to illuminate the mechanism of Pt(IV) prodrug activation and their use as versatile platforms for targeted chemotherapy.Downloads
Published
2015-03-25
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Section
Scientific Articles
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Copyright (c) 2015 Swiss Chemical Society
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
[1]
Chimia 2015, 69, 100, DOI: 10.2533/chimia.2015.100.