Platinum(IV) Carboxylate Prodrug Complexes as Versatile Platforms for Targeted Chemotherapy

Authors

  • Jun Xiang Ong Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543
  • Siew Qi Yap Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543
  • Daniel Yuan Qiang Wong Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543
  • Chee Fei Chin Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543
  • Wee Han Ang Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543; NUS Graduate School of Integrative Sciences and Engineering, Centre for Life Sciences (CeLS), 28 Medical Drive, Singapore 117456. chmawh@nus.edu.sg

DOI:

https://doi.org/10.2533/chimia.2015.100

Keywords:

Anticancer, Cisplatin, Oxaliplatin, Platinum(iv) prodrugs, Targeted chemotherapy

Abstract

Kinetically-inert Pt(IV) carboxylate complexes have emerged in recent years as candidates for the development of next-generation platinum anticancer drugs. Being native prodrugs of clinically-important Pt(II) chemotherapeutic agents, the Pt(IV) scaffold can be exploited to incorporate additional functionalities while keeping the Pt(II) pharmacophore intact. This mini-review examines recent work performed to illuminate the mechanism of Pt(IV) prodrug activation and their use as versatile platforms for targeted chemotherapy.
CHIMIA Vol. 69 No. 3 (2015): Singapore - Swiss Connections

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Published

2015-03-25

Issue

Vol. 69 No. 3 (2015): Singapore - Swiss Connections

Section

Scientific Articles

License

Copyright (c) 2015 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
J. X. Ong, S. Q. Yap, D. Y. Q. Wong, C. F. Chin, W. H. Ang, Chimia 2015, 69, 100, DOI: 10.2533/chimia.2015.100.