Divergent Reaction Mechanisms in the Aminofluorination of Alkenes

Authors

  • Wangqing Kong University of Zürich, Department of Chemistry, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland
  • Estíbaliz Merino University of Zürich, Department of Chemistry, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland
  • Cristina Nevado University of Zürich, Department of Chemistry, Winterthurerstrasse 190, CH-8057 Zürich,,, Switzerland. cristina.nevado@chem.uzh.ch

DOI:

https://doi.org/10.2533/chimia.2014.430

Keywords:

Alkenes, Aminofluorination, Difunctionalization

Abstract

The aminofluorination of alkenes has become an attractive platform for the synthesis of ?-amino-fluorinated compounds, valuable building blocks in medicinal and agricultural chemistry. The novel methodologies disclosed in recent years have unraveled a broad array of reaction mechanisms, so that the interest in these transformations transcends the mere synthetic aspects. This review aims to summarize the most relevant findings in this area attending at the nature of the fluorine source, and thus the specific mechanism operating in each of these transformations, namely electrophilic, nucleophilic, radical, and late transition metal-catalyzed reactions.

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Published

2014-06-26

Issue

Section

Scientific Articles

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