Efficient Synthesis of New Fluorinated Building Blocks by means of Hydroformylation

Authors

  • Lidia Fanfoni Institut für Organische Chemie Albert-Ludwigs-Universität Freiburg Albertstrasse 21, 79104 Freiburg i. Bg., Germany
  • Lisa Diab Institut für Organische Chemie Albert-Ludwigs-Universität Freiburg Albertstrasse 21, 79104 Freiburg i. Bg., Germany
  • Tomas Smejkal Syngenta Crop Protection Münchwilen AG Schaffhauserstrasse, CH-4332 Stein, Switzerland. tomas.smejkal@syngenta.com
  • Bernhard Breit Institut für Organische Chemie Albert-Ludwigs-Universität Freiburg Albertstrasse 21, 79104 Freiburg i. Bg., Germany. bernhard.breit@chemie.uni-freiburg.de

DOI:

https://doi.org/10.2533/chimia.2014.371

Keywords:

Aldehydes, Alkenes, Hydroformylation, Organofluorides, Rhodium

Abstract

Hydroformylation of fluorinated alkenes is an efficient method for the preparation of fluorinated functionalized building blocks for the synthesis of biologically active target structures. In this article we summarize known hydroformylation reactions of fluorinated olefins and we add new results from our research groups. Particular attention is paid to the remarkable influence of organofluorine substituents on catalyst activity, regio- and stereoselectivity of the hydroformylation reaction.
CHIMIA Vol. 68 No. 6 (2014): Fluorine Chemistry

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Published

2014-06-26

Issue

Vol. 68 No. 6 (2014): Fluorine Chemistry

Section

Scientific Articles

License

Copyright (c) 2014 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
L. Fanfoni, L. Diab, T. Smejkal, B. Breit, Chimia 2014, 68, 371, DOI: 10.2533/chimia.2014.371.