Surface Modification of Biomaterials for Conjugation with Human Fetal Osteoblasts

Authors

  • Françoise Borcard Institute of Chemical Sciences and Engineering EPFL, CH-1015 Lausanne, Switzerland
  • Phally Kong Institute of Chemical Sciences and Engineering EPFL, CH-1015 Lausanne, Switzerland
  • Céline Journot Institute of Chemical Sciences and Engineering EPFL, CH-1015 Lausanne, Switzerland
  • Davide Staedler Institute of Chemical Sciences and Engineering EPFL, CH-1015 Lausanne, Switzerland
  • Philip N. Sturzenegger Nonmetallic Inorganic Materials ETHZ, CH-8093 Zürich, Switzerland
  • Franziska Krauss Juillerat Nonmetallic Inorganic Materials ETHZ, CH-8093 Zürich, Switzerland
  • Urs T. Gonzenbach Nonmetallic Inorganic Materials ETHZ, CH-8093 Zürich, Switzerland
  • Lucienne Juillerat-Jeanneret University Institute of Pathology CHUV-UNIL, CH-1011 Lausanne, Switzerland
  • Sandrine Gerber-Lemaire Institute of Chemical Sciences and Engineering EPFL, CH-1015 Lausanne, Switzerland. Sandrine.Gerber@epfl.ch

DOI:

https://doi.org/10.2533/chimia.2013.213

Keywords:

Cell adhesions, Copper-free click reaction, Functionalized biomaterials, Human fetal osteoblasts

Abstract

Surface functionalization of hydroxyapatite (HA) and ?-tricalcium phosphate (TCP) bioceramics with chemical ligands containing a pyrrogallol moiety was developed to improve the adhesion of bone cell precursors to the biomaterials. Fast and biocompatible copper-free click reaction with azido-modified human fetal osteoblasts resulted in improved cell binding to both HA and TCP bioceramics, opening the way for using this methodology in the preparation of cell-engineered bone implants.
CHIMIA Vol. 67 No. 4(2013): Laureates: Awards and Honors, SCS Fall Meeting 2012

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Published

2013-04-24

Issue

Vol. 67 No. 4 (2013): Laureates: Awards and Honors, SCS Fall Meeting 2012

Section

Scientific Articles

License

Copyright (c) 2013 Swiss Chemical Society

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

How to Cite

[1]
Chimia 2013, 67, 213, DOI: 10.2533/chimia.2013.213.